General Information

  • ID:  hor006533
  • Uniprot ID:  P18830
  • Protein name:  Adipokinetic prohormone type 1
  • Gene name:  NA
  • Organism:  Schistocerca nitens (Vagrant locust) (Gray bird grasshopper)
  • Family:  AKH/HRTH/RPCH family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Schistocerca (genus), Cyrtacanthacridinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0007629 flight behavior
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QLNFTPNWGTGKRDAGDYGDPYSFLYRLIQAEARKMSGCSN
  • Length:  41(23-63)
  • Propeptide:  MVQRCLVVALLVVVVAAALCSAQLNFTPNWGTGKRDAGDYGDPYSFLYRLIQAEARKMSGCSN
  • Signal peptide:  MVQRCLVVALLVVVVAAALCSA
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Threonine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  39-39
  • Structure ID:  AF-P18830-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006533_AF2.pdbhor006533_ESM.pdb

Physical Information

Mass: 534277 Formula: C203H304N58O63S2
Absent amino acids: HV Common amino acids: G
pI: 8.48 Basic residues: 5
Polar residues: 17 Hydrophobic residues: 10
Hydrophobicity: -86.1 Boman Index: -9386
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 45.37
Instability Index: 1524.39 Extinction Coefficient cystines: 9970
Absorbance 280nm: 249.25

Literature

  • PubMed ID:  2294116
  • Title:  The structurally similar neuropeptides adipokinetic hormone I and II are derived from similar, very small mRNAs.